Home to the Internal Revenue Service's processing center with America's lowest ZIP code (00501), Holtsville offers a strategic location for houses for rent in Suffolk County. This well-established Long Island community spans both Brookhaven and Islip townships, providing renters convenient access to major employment centers along the Long Island Expressway. The Nicolls Road corridor features spacious rental houses near professional office complexes, while neighborhoods near Waverly Avenue showcase well-maintained rental properties with generous yards. Commuters appreciate the 15-minute drive to the Ronkonkoma LIRR station for Manhattan-bound trains, while local professionals enjoy quick access to major employers in Hauppauge and Islandia. The area around the Harold H. Malkmes Wildlife Education Center offers rental houses near walking trails and recreational facilities, while the Blue Point Road area provides easy access to shopping centers and dining options. Holtsville's steady rental market and convenient mid-island location make it an attractive choice for those seeking quality rental homes in Suffolk County.