Pennsylvania Neighborhoods S
- Salem Square (1)
- Scott Township (7)
- Shadyside (50)
- Sheraden (12)
- Shiloh (5)
- Sixth Ward (3)
- Slatington Historic District (1)
- Society Hill (29)
- South Ardmore (5)
- South Duquesne Heights (1)
- South East Hills (4)
- South Easton (7)
- South Harrisburg (3)
- South Philadelphia East (24)
- South Philadelphia West (63)
- South Shore (3)
- South Side (27)
- South Suburban Erie (9)
- Southeast Community (6)
- Southeast Erie (4)
- Southeast Reading (2)
- Southside (2)
- Southside Flats (116)
- Southside Slopes (28)
- Southside-Lehigh (15)
- Southwest Center City (62)
- Southwest Reading (5)
- Southwest York (1)
- Spring Hill City View (2)
- Spring Ridge (2)
- Springetts Manor-Yorklyn (3)
- Spruce Hill (85)
- Spry (3)
- Squirrel Hill North (26)
- Squirrel Hill South (64)
- St Lawrence (3)
- St Mary's (3)
- Stadium District (4)
- Stanton Heights (3)
- State College South (1)
- Stevens (2)
- Stonybrook-Wilshire (3)
- Strip District (12)
- Sun Hill (2)
- Sun Village (4)
- Swisshelm Park (3)