Pennsylvania Neighborhoods S
- Salem Square (5)
- Schnecksville Historic District (1)
- Scott Township (5)
- Sewickley Heights (1)
- Shade Gap (2)
- Sheraden (4)
- Shiloh (5)
- Sixth Ward (2)
- Slatington Historic District (4)
- Society Hill (24)
- South Ardmore (5)
- South Duquesne Heights (8)
- South Easton (5)
- South Harrisburg (2)
- South Philadelphia East (21)
- South Philadelphia West (61)
- South Shore (3)
- South Side (26)
- South Suburban Erie (13)
- Southeast Community (6)
- Southeast Erie (3)
- Southeast Reading (9)
- Southside (5)
- Southside Flats (102)
- Southside Slopes (42)
- Southside-Lehigh (21)
- Southwest Center City (43)
- Southwest Reading (5)
- Southwest York (13)
- Spring Hill City View (5)
- Spring Ridge (2)
- Springetts Manor-Yorklyn (3)
- Spruce Hill (72)
- Spry (10)
- Squirrel Hill North (42)
- Squirrel Hill South (114)
- St Mary (1)
- St Mary's (5)
- Stadium District (3)
- Stanton Heights (13)
- State College South (1)
- Stevens (7)
- Stonybrook-Wilshire (3)
- Strip District (20)
- Summer Hill (1)
- Sun Hill (2)
- Sun Village (4)
- Swisshelm Park (2)
- Swoyersville (1)