Pennsylvania Neighborhoods S
- Salem Square (1)
- Scott Township (6)
- Shadyside (67)
- Sheraden (8)
- Shiloh (8)
- Sixth Ward (3)
- Slatington Historic District (2)
- Society Hill (33)
- South Ardmore (7)
- South Duquesne Heights (3)
- South East Hills (1)
- South Easton (9)
- South Harrisburg (1)
- South Philadelphia East (35)
- South Philadelphia West (63)
- South Shore (5)
- South Side (36)
- South Suburban Erie (4)
- Southeast Community (6)
- Southeast Erie (4)
- Southeast Reading (2)
- Southside (3)
- Southside Flats (104)
- Southside Slopes (25)
- Southside-Lehigh (23)
- Southwest Center City (47)
- Southwest Reading (2)
- Southwest York (7)
- Springetts Manor-Yorklyn (3)
- Spruce Hill (110)
- Spry (3)
- Squirrel Hill North (38)
- Squirrel Hill South (76)
- St Lawrence (1)
- St Mary (1)
- St Mary's (4)
- Stadium District (5)
- Stanton Heights (11)
- State College South (1)
- Stevens (6)
- Stonybrook-Wilshire (1)
- Strip District (13)
- Summer Hill (1)
- Sun Hill (2)
- Sun Village (3)
- Swoyersville (2)