Pennsylvania Neighborhoods S
- Salem Square (7)
- Scott Township (6)
- Sewickley Heights (1)
- Shade Gap (2)
- Sheraden (8)
- Shiloh (6)
- Sixth Ward (2)
- Slatington Historic District (1)
- Society Hill (14)
- South Ardmore (10)
- South Duquesne Heights (8)
- South East Hills (1)
- South Easton (10)
- South Harrisburg (1)
- South Philadelphia East (29)
- South Philadelphia West (61)
- South Shore (5)
- South Side (39)
- South Suburban Erie (5)
- Southeast Community (4)
- Southeast Erie (3)
- Southeast Reading (12)
- Southside (3)
- Southside Flats (103)
- Southside Slopes (38)
- Southside-Lehigh (29)
- Southwest Center City (48)
- Southwest Reading (2)
- Southwest York (14)
- Spring Hill City View (8)
- Spring Ridge (1)
- Springetts Manor-Yorklyn (3)
- Spruce Hill (70)
- Spry (5)
- Squirrel Hill North (18)
- Squirrel Hill South (48)
- St Mary (1)
- St Mary's (9)
- Stadium District (4)
- Stanton Heights (16)
- State College South (3)
- Stevens (3)
- Stonybrook (1)
- Stonybrook-Wilshire (3)
- Strip District (16)
- Sun Hill (1)
- Sun Village (1)
- Swisshelm Park (2)
- Swoyersville (3)