Known as the "Birthplace of Biotechnology," South San Francisco offers a strategic Peninsula location anchored by industry pioneers like Genentech and Amgen. Situated just 2.5 miles from San Francisco International Airport, the city combines residential neighborhoods with excellent transit connectivity through BART, Caltrain, and ferry service to the East Bay. Houses in the Westborough district feature hillside vistas overlooking San Francisco Bay, while homes near downtown Grand Avenue put residents within walking distance of local cafes and specialty shops. The average monthly rent for a three-bedroom home is approximately $4,068. Established neighborhoods like Sunshine Gardens and Winston Manor offer convenient access to both the biotech district and transportation hubs, making commutes manageable to San Francisco, Silicon Valley, and the East Bay. The 33-acre Orange Memorial Park serves as a central gathering space with sports facilities and playgrounds, while Oyster Point Marina provides waterfront recreation. Just west of residential areas, San Bruno Mountain State and County Park offers more than 12 miles of hiking trails with sweeping bay views.